Selected Publications

For a full list click here


SOD Enzymes and Microbial Pathogens: Surviving the Oxidative Storm of Infection.

Broxton CN, Culotta VC.

PLoS Pathog. 2016 Jan 7;12(1):e1005295. doi: 10.1371/journal.ppat.1005295. eCollection 2016 Jan. No abstract available.

PMID: 26742105 Free PMC Article


Candida albicans adapts to host copper during infection by swapping metal cofactors for superoxide dismutase.

Li CX, Gleason JE, Zhang SX, Bruno VM, Cormack BP, Culotta VC.

Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):E5336-42. doi: 10.1073/pnas.1513447112. Epub 2015 Sep 8.

PMID: 26351691


Candida albicans SOD5 represents the prototype of an unprecedented class of Cu-only superoxide dismutases required for pathogen defense.

Gleason JE, Galaleldeen A, Peterson RL, Taylor AB, Holloway SP, Waninger-Saroni J, Cormack BP, Cabelli DE, Hart PJ, Culotta VC.

Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):5866-71. doi: 10.1073/pnas.1400137111. Epub 2014 Apr 7.

PMID: 24711423


Species-specific activation of Cu/Zn SOD by its CCS copper chaperone in the pathogenic yeast Candida albicans.

Gleason JE, Li CX, Odeh HM, Culotta VC.

J Biol Inorg Chem. 2014 Jun;19(4-5):595-603. doi: 10.1007/s00775-013-1045-x. Epub 2013 Sep 17.

PMID: 24043471


A manganese-rich environment supports superoxide dismutase activity in a Lyme disease pathogen, Borrelia burgdorferi.

Aguirre JD, Clark HM, McIlvin M, Vazquez C, Palmere SL, Grab DJ, Seshu J, Hart PJ, Saito M, Culotta VC.

J Biol Chem. 2013 Mar 22;288(12):8468-78. doi: 10.1074/jbc.M112.433540. Epub 2013 Feb 2.

PMID: 23376276


SOD1 integrates signals from oxygen and glucose to repress respiration.

Reddi AR, Culotta VC.

Cell. 2013 Jan 17;152(1-2):224-35. doi: 10.1016/j.cell.2012.11.046.

PMID: 23332757


Battles with iron: manganese in oxidative stress protection.

Aguirre JD, Culotta VC.

J Biol Chem. 2012 Apr 20;287(17):13541-8. doi: 10.1074/jbc.R111.312181. Epub 2012 Jan 13. Review.

PMID: 22247543


Regulation of manganese antioxidants by nutrient sensing pathways in Saccharomyces cerevisiae.

Reddi AR, Culotta VC.

Genetics. 2011 Dec;189(4):1261-70. doi: 10.1534/genetics.111.134007. Epub 2011 Sep 16.

PMID: 21926297


Probing in vivo Mn2+ speciation and oxidative stress resistance in yeast cells with electron-nuclear double resonance spectroscopy.

McNaughton RL, Reddi AR, Clement MH, Sharma A, Barnese K, Rosenfeld L, Gralla EB, Valentine JS, Culotta VC, Hoffman BM.

Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15335-9. doi: 10.1073/pnas.1009648107. Epub 2010 Aug 11.

PMID: 20702768


Activation of Cu,Zn-superoxide dismutase in the absence of oxygen and the copper chaperone CCS.

Leitch JM, Jensen LT, Bouldin SD, Outten CE, Hart PJ, Culotta VC.

J Biol Chem. 2009 Aug 14;284(33):21863-71. doi: 10.1074/jbc.M109.000489. Epub 2009 Jun 19.

PMID: 19542232


Biological effects of CCS in the absence of SOD1 enzyme activation: implications for disease in a mouse model for ALS.

Proescher JB, Son M, Elliott JL, Culotta VC.

Hum Mol Genet. 2008 Jun 15;17(12):1728-37. doi: 10.1093/hmg/ddn063. Epub 2008 Mar 12.

PMID: 18337307


The effects of mitochondrial iron homeostasis on cofactor specificity of superoxide dismutase 2.

Yang M, Cobine PA, Molik S, Naranuntarat A, Lill R, Winge DR, Culotta VC.

EMBO J. 2006 Apr 19;25(8):1775-83. Epub 2006 Apr 6.

PMID: 16601688


Activation of CuZn superoxide dismutases from Caenorhabditis elegans does not require the copper chaperone CCS.

Jensen LT, Culotta VC.

J Biol Chem. 2005 Dec 16;280(50):41373-9. Epub 2005 Oct 18.

PMID: 16234242


Mechanisms for activating Cu- and Zn-containing superoxide dismutase in the absence of the CCS Cu chaperone.

Carroll MC, Girouard JB, Ulloa JL, Subramaniam JR, Wong PC, Valentine JS, Culotta VC.

Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):5964-9.

PMID: 15069187


Manganese activation of superoxide dismutase 2 in Saccharomyces cerevisiae requires MTM1, a member of the mitochondrial carrier family.

Luk E, Carroll M, Baker M, Culotta VC.

Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10353-7. Epub 2003 Jul 30.

PMID: 12890866


A novel NADH kinase is the mitochondrial source of NADPH in Saccharomyces cerevisiae.

Outten CE, Culotta VC.

EMBO J. 2003 May 1;22(9):2015-24.

PMID: 12727869


A fraction of yeast Cu,Zn-superoxide dismutase and its metallochaperone, CCS, localize to the intermembrane space of mitochondria. A physiological role for SOD1 in guarding against mitochondrial oxidative damage.

Sturtz LA, Diekert K, Jensen LT, Lill R, Culotta VC.

J Biol Chem. 2001 Oct 12;276(41):38084-9. Epub 2001 Aug 10.

PMID: 11500508


Metallochaperones, an intracellular shuttle service for metal ions.

O'Halloran TV, Culotta VC.

J Biol Chem. 2000 Aug 18;275(33):25057-60. Review. No abstract available.

PMID: 10816601


Undetectable intracellular free copper: the requirement of a copper chaperone for superoxide dismutase.

Rae TD, Schmidt PJ, Pufahl RA, Culotta VC, O'Halloran TV.

Science. 1999 Apr 30;284(5415):805-8.

PMID: 10221913 Free Article


Chaperone-facilitated copper binding is a property common to several classes of familial amyotrophic lateral sclerosis-linked superoxide dismutase mutants.

Corson LB, Strain JJ, Culotta VC, Cleveland DW.

Proc Natl Acad Sci U S A. 1998 May 26;95(11):6361-6.


Metal ion chaperone function of the soluble Cu(I) receptor Atx1.

Pufahl RA, Singer CP, Peariso KL, Lin SJ, Schmidt PJ, Fahrni CJ, Culotta VC, Penner-Hahn JE, O'Halloran TV.

Science. 1997 Oct 31;278(5339):853-6.


The copper chaperone for superoxide dismutase.

Culotta VC, Klomp LW, Strain J, Casareno RL, Krems B, Gitlin JD.

J Biol Chem. 1997 Sep 19;272(38):23469-72.


Superoxide dismutase protects calcineurin from inactivation.

Wang X, Culotta VC, Klee CB.

Nature. 1996 Oct 3;383(6599):434-7.


The ATX1 gene of Saccharomyces cerevisiae encodes a small metal homeostasis factor that protects cells against reactive oxygen toxicity.

Lin SJ, Culotta VC.

Proc Natl Acad Sci U S A. 1995 Apr 25;92(9):3784-8.

PMID: 7731983